JOIN US
Build AI's Next Frontier
Biology remains one of the most consequential unsolved frontiers for AI. Join us in advancing the foundations of AI, with direct applications in human health, biological engineering, and biosecurity.
The Work
The foundational techniques to scale AI on biology
are still being invented.
At Radical Numerics, you’ll develop the architectures, representations, and training systems needed for AI to learn across biological signals and scales. This means solving fundamental problems in how models learn, reason, and generalize, and how we evaluate
what they understand.
You’ll work on these foundations of AI while staying close to their scientific applications. The models we build could help researchers understand disease, design new biological functions,
and strengthen biosecurity.
Solve Biology with us.
TEAM FILM
Meet the Founders

CULTURE
We Bet on the
Non-Obvious
Radical Numerics grew out of unconventional bets on problems others considered too hard.
We’ve questioned assumptions and pursued approaches the field doubted would work. That still shapes how we work today.
We look at problems from different perspectives, reason from first principles, and build from the ground up when existing approaches fall short. We test our ideas rigorously and change course when the evidence calls for it. Building something new requires taking an uncertain path and doing the work to find out where it leads.
[01]
Rigor
Clear hypotheses. Disciplined experiments. Evidence that survives scrutiny.
[02]
First Principles
If the existing architecture doesn't fit the problem, build another.
[03]
Collaboration
AI researchers, biologists, systems researchers, and numerical scientists working on the same problem.
[04]
Responsibility
Advancing biological intelligence and strengthening biosecurity together.
CAREERS
Open Roles
Operations
05 open roles
- 01Business AssociateOperationsSan Francisco—
- 02Head of Business DevelopmentOperationsSan Francisco—
- 03Marketing AssociateOperationsSan Francisco—
- 04People Operations ManagerOperationsSan Francisco—
- 05Technical RecruiterOperationsSan Francisco—
R&D
12 open roles
- 01Applications EngineerR&DSan Francisco—
- 02Member of Technical Staff, AI BioR&DSan FranciscoOn-site
- 03Member of Technical Staff, AI Engineering for BiosecurityR&DSan Francisco—
- 04Member of Technical Staff, Distributed SystemsR&DSan Francisco / TokyoOn-site
- 05Member of Technical Staff, InferenceR&DSan Francisco—
- 06Member of Technical Staff, Infrastructure and Training SystemsR&DSan Francisco / TokyoOn-site
- 07Member of Technical Staff, Mechanistic InterpretabilityR&DSan Francisco / TokyoOn-site
- 08Member of Technical Staff, ML EngineerR&DSan FranciscoOn-site
- 09Member of Technical Staff, Post-TrainingR&DSan Francisco / TokyoOn-site
- 10Member of Technical Staff, Pretraining ScienceR&DSan Francisco / TokyoOn-site
- 11Product Lead - DiscoveryR&DSan Francisco—
- 12Product Lead, BiodefenseR&DSan Francisco—
- Business AssociateSan Francisco · —Apply
- Head of Business DevelopmentSan Francisco · —Apply
- Marketing AssociateSan Francisco · —Apply
- People Operations ManagerSan Francisco · —Apply
- Technical RecruiterSan Francisco · —Apply
- Applications EngineerSan Francisco · —Apply
- Member of Technical Staff, AI BioSan Francisco · On-siteApply
- Member of Technical Staff, AI Engineering for BiosecuritySan Francisco · —Apply
- Member of Technical Staff, Distributed SystemsSan Francisco / Tokyo · On-siteApply
- Member of Technical Staff, InferenceSan Francisco · —Apply
- Member of Technical Staff, Infrastructure and Training SystemsSan Francisco / Tokyo · On-siteApply
- Member of Technical Staff, Mechanistic InterpretabilitySan Francisco / Tokyo · On-siteApply
- Member of Technical Staff, ML EngineerSan Francisco · On-siteApply
- Member of Technical Staff, Post-TrainingSan Francisco / Tokyo · On-siteApply
- Member of Technical Staff, Pretraining ScienceSan Francisco / Tokyo · On-siteApply
- Product Lead - DiscoverySan Francisco · —Apply
- Product Lead, BiodefenseSan Francisco · —Apply